For many years, diseases such as COPD and asthma were considered to be a result primarily of environmental factors, such as smoking or exposure to environmental pollutants. However, …

Apr 12, 2022 · Chronic obstructive pulmonary disease (COPD) is a deadly and highly morbid disease. Susceptibility to and heterogeneity of COPD are incompletely explained by …

Apr 21, 2020 · Keywords: COPD, ethnicity-specific, SNP heritability, susceptible loci, BLUP-filtered SNP, genetic prediction, ethnicity difference Citation: Gim J, An J, Sung J, Silverman …

Objectives: To assess the heritability and coheritability of four major COPD-related phenotypes (measurements of FEV 1, FEV 1 /FVC, percent emphysema, and percent gas trapping), and …

Apr 17, 2023 · Chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide, is highly heritable. While COPD is clinically defined by applying thresholds to …

Heritability refers to the proportion of variation in a trait that can be attributed to genetic differences among individuals in a population. In the case of COPD, research suggests that …

Rationale: Previous studies of chronic obstructive pulmonary disease (COPD) have suggested that genetic factors play an important role in the development of disease. However, single …

Clinical COPD was defined by respiratory symptoms plus airflow obstruction. Biometric models of genetic and environmental latent factors were used to estimate the heritability after adjust-ing …

Regardless of the sensitivity of the tests used to assess the presence of the disease, evidence indicates that susceptibility to COPD varies between individuals. There is widespread …

Background: Chronic Obstructive Pulmonary Disease (COPD) development may be associated with CNV in susceptible genomic regions. CNV also contributes to COPD heritability.CNVs in …